Publications

Toxoplasma gondii is an obligate intracellular parasite infecting up to one-third of the human population. There are currently no treatment options which could eradicate the parasite from the infected host. A gold-standard, confirmatory diagnostic bioassay test for toxoplasmosis uses microscopic identification of T. gondii cysts in brain samples of mice inoculated with biological Read more…

Abstract Background/Objectives: Acridine, an aromatic heterocyclic compound, serves as a basis for the synthesis of potent bioactive derivatives, displaying a broad spectrum of biological activity, such as antibacterial, antitumor, and antiparasitic activity. With the ability to undergo various types of electrophilic substitutions, introducing different side chains could lead to compounds Read more…

Abstract Toxoplasma gondii is an obligate intracellular parasite existing in three infectious life stages—tachyzoites, bradyzoites, and sporozoites. Rupture of tissue cysts and re-conversion of bradyzoites to tachyzoites leads to reactivated toxoplasmosis (RT) in an immunocompromised host. The aim of this study was to apply ImageJ software for analysis of T. gondii brain cysts Read more…